EFFECTS OF ANTIMALARIAL DRUGS ON OESTROUS CYCLE AND UTERINE CONTRACTILITY IN RATS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Malaria is increasingly a health burden globally with children under the age of 5 and pregnant women being the most vulnerable. Several antimalarials are available in the market today however; the safety data in pregnancy is inadequate especially the first trimester of pregnancy. The study was carried out in both pregnant and non-pregnant wistar rats to evaluate the effect of these antimalarial drugs on the oestrous cycle as well as on the uterine smooth muscle contractility. All the antimalarial drugs in this study (AT 3.2 mg/kg loading dose and 1.6 mg/kg maintenance dose for 7 days; CQ 2.5 mg/kg every 4 hours; QN 20 mg/kg loading dose and 10 mg/kg maintenance dose 8 hourly for 7 days and SP 25 mg/1.25 mg/kg once); showed a desynchronization of the normal oestrous cycle. Proestrus phase was increased by all the antimalarial drugs except for AT, oestrus phase was decreased by all but significantly by QN and metoestrus was increased by all except SP which decreased it significantly while the dioestrus phase, a decrease was observed. On isolated uterine smooth muscle of pregnant rat, artemether (AT, 16 µg/ml – 1280 µg/ml) Chloroquine (CQ, 4 mg/ml – 32 mg/ml), quinine (QN 100 ng/ml – 800 ng/ml) and sulphadoxine /pyrimethamine (SP, 100 µg/ml – 400 µg/ml ), had no agonist effect on the uterus but AT (16 µg/ml – 1280 µg/ml), CQ (16 mg/ml) and SP (100 µg/ml) produced a reduction in oxytocin induced contraction of the pregnant uterus. In conclusion, this study showed that these antimalarial drugs caused a desynchronization of the normal oestrous cycle suggesting a possible effect on the menstrual cycle in women of child bearing age while the reduction in the oxytocin induced contraction could translate to ill effect especially in late pregnancy and during labour.
Related Project Materials
IMPACT OF SOCIAL MEDIA ON CONSTRUCTION SMEs BUSINESSES IN ABUJA
ABSTRACT
Since the advent of social media in the early 2000s, its influence on the day to day life of people has impacted the way they co...
ECONOMIC OPERATION AND INTEGRATION IN WEST AFRICA (1999-2010)
Abstract
This study is on economic operation and integration in West Africa (1999-2010). The total population for...
FACTORS INFLUENCING FEMALE PARTICIPATION IN SPORTS AMONG UNDERGRADUATE STUDENTS
ABSTRACT
This study in its totality is an attempt to investigate the factors influencing female participation in sports amo...
AN IMPROVED IMAGE STEGANOGRAPHY BASED ON LEAST SIGNIFICANT BIT MATCHING REVISITED (LSBMR) USING SOBEL EDGE DETECTION
ABSTRACT
Image steganography is the science of hiding data for securing confidential communication and it is the most popular type of car...
TEENAGE PREGNANCY AND HOW IT AFFECTS EDUCATIONAL DEVELOPMENT OF OUR TEENAGERS
ABSTRACT
The main concern of this study was to final out the teenage pregnancy and how it affects the educational develo...
THE ROLE OF FORENSIC ACCOUNTING FOR SECURITIES FRAUD INVESTIGATIONS
Abstract: THE ROLE OF FORENSIC ACCOUNTING FOR SECURITIES FRAUD INVESTIGATIONS
This study investigates the role of forens...
EARLY CHILDHOOD EDUCATION AND MORAL REASONING
ABSTRACT: Early childhood education (ECE) plays a critical role in develop...
THE IMPACT OF INFORMATION SYSTEMS ON PROJECT MANAGEMENT
THE IMPACT OF INFORMATION SYSTEMS ON PROJECT MANAGEMENT
Abstract: This study aimed to assess the...
ETHNO-RELIGIOUS CONFLICTS IN NIGERIA; ISSUES, CHALLENGES AND SOLUTIONS
Background of the study
Ethnic consciousness is the loyalty or attachment to an ethnic group either as...
ASSESSMENT OF THE IMPACT OF ACADEMIC STAFF UNION OF UNIVERSITIES’ (ASUU) INDUSTRIAL STRIKES ON THE STATE OF LEARNING FACILITIES IN BENUE STATE UNIVERSITY (1999-2015)
ABSTRACT
This study assess the Impact of ASUU Strikes on the State of Learning Facilities in Benue State University from 1999-2015 with t...
